SamLab vs Prolis
Prolis laboratory information system · Cloud-based or on-premise (vendor)
The short verdict
Prolis is a US-market LIS for CLIA-certified laboratories, from physician-office to reference and toxicology, with HL7/FHIR exchange, bidirectional analyzer connectivity and 837/835 billing built in. SamLab is an offline-first LIS with a published price sold worldwide. Prolis wins on US billing rails; SamLab wins on outage resilience, price transparency and a free trial you can run today.
In the vendor’s words: Prolis describes itself as a laboratory information system built for modern diagnostic and clinical laboratories, connecting specimen orders, analyzer results, EMR integrations and billing in one system, with cloud-based or on-premise options.
SamLab vs Prolis — side by side
SamLab’s column reflects our published plans. Prolis’s column is what the vendor states on its own site, read on 2026-09-03; where the vendor does not say, the cell says so.
| Factor | SamLab | Prolis |
|---|---|---|
| Deployment | Offline-first desktop with cloud sync | Cloud-based or on-premise |
| Works through an internet outage | Yes — registration, billing, results and reports keep running | Not stated by the vendor; on-premise option exists |
| Pricing model | Yearly subscription in your own currency | Quote-based |
| Public, transparent pricing | Yes — every plan price is on the pricing page | Not published (directory: contact vendor) |
| Analyzer interfacing | ASTM, HL7 and serial/TCP interfaces with IQC (Pro and above) | Bidirectional analyzer connectivity (Prolis Bridge); HL7/FHIR |
| Accreditation-ready records (ISO 15189 style) | Reference ranges with units, verifier identity, retained amendment history, specimen traceability | Built for CLIA-certified US laboratories; confirm the evidence pack in a demo |
| Where your data lives | On your own machine first; encrypted off-site backup and export | Vendor cloud or your own server |
| Free trial on your own data | 7-day free trial, no card | Free demo; a directory lists a free trial |
| Typical laboratory | Independent and hospital-attached clinical laboratories | US physician-office, reference, clinical, toxicology, pathology and molecular laboratories |
An honest read
No software wins on everything. Here is where each genuinely leads.
Where Prolis wins
- US insurance billing built in — 837/835 EDI, per the vendor
- HL7 and FHIR data exchange, and bidirectional analyzer connectivity through Prolis Bridge
- Cloud or on-premise deployment, your choice
- Explicitly intended for CLIA-certified US laboratories, including toxicology and molecular
Where SamLab wins
- Keeps working through an internet outage in either edition, then syncs
- Published plan prices in your own currency; a 7-day free trial without a card
- Sold and supported outside the United States as well
- Your data on your own machine first, with export
Pick Prolis if…
you bill US insurers electronically and want 837/835 EDI inside the LIS from day one.
Pick SamLab if…
you are outside the US insurance system, or you want a laboratory that keeps running offline with a price you can read first.
What Prolis charges
Not published — the vendor quotes after a sales conversation (checked 2026-09-03)
Vendor contact page · checked 2026-09-03SamLab’s pricing is public
A yearly subscription in your own currency, with no onboarding fee and a 7-day free trial. Every plan price is on the pricing page.
SamLab vs Prolis — FAQs
Does Prolis publish its pricing?+
No. The vendor site and its Capterra listing both direct buyers to contact the vendor. SamLab publishes every plan price on its pricing page.
Is Prolis available outside the United States?+
The vendor states the product is intended for use in CLIA-certified diagnostic laboratory testing facilities within the United States market. SamLab is sold internationally with pricing in local currency.
Which is better for a small clinical laboratory?+
If you bill US insurers, Prolis brings the EDI rails. If your priority is a system that keeps billing and reporting through connection loss, with a published price and a free trial, SamLab fits. Run both against your own workflow before deciding.
Sources for what we say about Prolis
Keep comparing
Vendor details are taken from each vendor’s own public website on the date shown and may change. We compare on published capabilities, not on internals we cannot verify. Confirm current features and pricing directly with the vendor and in a trial. SamLab details reflect our published plans. Vendor names are used only to identify the products compared.
Try the whole lab, free for 7 days.
No card. No catch. Run SamLab on your own data — online or offline — and feel the difference before you pay anything.